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Materials for Orthopedic Bone Reconstruction

by Ossiform | November 20, 2023 | Scientific Blog Posts​

Bone is the second most transplanted tissue worldwide; in fact, bone grafts and bone substitute materials are used in over four million operations annually. Bone constitutes an essential part of the musculoskeletal system that is vital for maintaining our daily activities.

However, bone integrity may be compromised by tumors, trauma, infection, necrosis, congenital bone defects, and more, which may necessitate reconstructive surgery.

In the ocean of accessible biomaterials for the reconstruction of bone, mainly revolving around metals and alloys, polymeric materials and bioceramics, identifying the most suitable reconstructive material can be difficult. 

Nevertheless, following the surge in bone research and a flourishing use of bone graft substitutes within the orthopedic field, biomaterials will reach clinics with exceptional and regenerative approaches to ultimately advance the field of bone reconstruction

Hydrogels versus Scaffolds: When to Choose What?

by Ossiform | August 24, 2023 | Scientific Blog Posts​

In modern research, a dichotomy of somewhat opposing methods is emerging; porous, structural scaffolds versus elastic, synthetic hydrogels. 

Both methods enable the creation of three-dimensional microphysiological systems (MPS) and thus carry the potential to more accurately mimic in vivo environments compared to 2D cultures. Each method presents their respective scientific advantages and limitations in recapitulating the properties of native tissues and is thus suitable for mimicking different types of tissues or in vivo environments. In consequence, to bridge this dichotomy, a distinction between when each method is more appropriate is necessary

How do bones function and what are they made of?​

by Ossiform | June 27, 2022 | Scientific Blog Posts​

The human body is composed of multiple specialized tissue types, each with unique properties which are tailored to support the different functions throughout the body. ​

One such tissue is our bones, which most of us would characterize as rigid, calcified structures that form the skeleton. Besides providing structure and stability to our bodies, together with our muscles and tendons, the skeleton also functions as a stem cell niche and a reservoir for inorganic ions like calcium and phosphate.​​​

The performance of 3D printed resorbable implants in the mandible of pigs​

by Ossiform | May 12, 2022 | Scientific Blog Posts​

3D printed patient specific implants derived from CAD/CAM-based technologies are presented as an alternative to preformed bone graft substitutes. Yet, today, clinicians must still choose between patient specificity or implant properties that are favorable for bone remodeling.

In this pilot study, the 3D printed P3D Bone has been directly compared to a commercially available off-the-shelf β-tricalcium phosphate implant in relation to defects in the mandible ramus of pigs. 

What 3D printing is all about

​by Ossiform | Jun 18, 2021 | BL​OG​​

3D printing may sound like something from a galaxy far, far away, but the technology has been around for quite some time. Throughout the years, scientists from all over the world have printed everything; from small food items to large scale houses, and in the medical industry, 3D printing is playing a key role in bettering both treatment, outcome, and overall patient satisfaction. 3D printing is providing a range of new possibilities for cost efficient production where less resources actually give you better results.

One of the many advantages of 3D printing is that you can test your ideas quickly – and if they don’t work, you can easily change them”, explains Philip Firouzian.​​

What are organoids and why are they important?​

by Ossiform ​| May 18, 2021 | Scientific Blog Posts

Organoids cover a wide range of three-dimensional multicellular in vitro human tissue constructs that are used to mimic its corresponding in vivo organ in research.

The word ‘organoid’ is relatively new and most commonly describes constructs derived from stem cells – either pluripotent or adult stem cells – from various organs. Still, stem cell-derived organoids are not the only type of organoid. In fact, there are a wide variety of organoids that are created through different types of cell culture systems. These include 3D bioprinted scaffolds, organ-on-chip, and microfluidics-based 3D cell culture models.​

Biofilm, a brief introduction​

​by Ossiform | Apr 16, 2021 | Scientific Blog Posts​

Biofilms are clusters of one or more living microorganisms, or microbes, such as bacteria, fungi, and viruses that are attached to a surface and embedded in a self-produced matrix designed for the survival of organisms.

And why should we pay attention to biofilms?​

How miniature tumors can be grown on P3D Scaffolds for cancer research​

​by Ossiform | Oct 21, 2020 | Scientific Blog Posts​

In the study of cancer, tumoroids (tumor-like organoids) represent a promising tool for cost-effective research and screening of anticancer therapies.​

How 3D cell culturing is revolutionizing the fields of disease modeling and regenerative medicine

​by Ossiform | Jul 19, 2020 | Scientific Blog Posts

The development of lifelike 3D bone environments represents a good example of how 3D printing technology is revolutionizing the future of medicine, yielding advances in biotechnology and drug development. Especially, with the capacity to overcome the shortcomings and drawbacks of conventional 2D cellular models and animal models, 3D cell cultures show huge potential in regenerative medicine and disease modeling.​​

​​Want to stay up to date with the latest biotech news from our scientists?​

That's why, We Print Bone

Our mission is to provide 3D printed natural bone implants to reduce complications, improve functional outcomes, and obtain faster recovery

Tailored properties, optimized for bone regeneration and relevant biomechanical thresholds

Fully remodels into new vascularized bone, tuned to offer balanced rates of resorption and new bone ingrowth

Patient matched designed with the patient's uniqueness and biomechanical factors in mind

Resorbable material with structural support, offering controlled cortical and cancellous components

P3D Bone Extremities – approval process ongoing

Our first 3D printed, resorbable P3D Bone with modifiable dimensions and a bone-like morphology

P3D Bone - under development

The next generation of resorbable and structural bone implants

We Print Bone​™

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