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​News from the Lab

Want to stay up to date with the latest biotech news from our scientists?​

New master's thesis project in collaboration with Ossiform

July 19, 2022 ​| News from the Lab​

At the end of summer, Laura will be starting her master's thesis project here at Ossiform. She is currently studying for a Master of Science in Chemical Engineering at the University of Southern Denmark.

Using our P3D Scaffolds, Laura will investigate potential antibacterial solutions and how they may be combined with our proprietary technology. Laura aims to develop a 3D printed bioceramic scaffold which minimizes the risk of biofilm formation through a constant release of antibacterial factors.​

We cannot wait to share her results with you.​​​

Collagen-producing osteoblasts​

May 31, 2022 | News from the Lab​​

The development of our bones is carried out by the bone-forming cells called osteoblasts. Through a process known as osteogenesis, the osteoblasts form the bone by producing a soft framework, consisting primarily of collagen, which is then strengthened and hardened by the addition of calcium phosphate. The combination of the flexible collagen and the hard calcium phosphate is what makes our bones sturdy enough to withstand loadbearing and stress.

Collagen production is therefore a good initial measure of bone forming osteoblast activity. These confocal images of osteoblasts cultured on P3D Scaffolds show the osteoblasts (in blue) and the surrounding osteoblast-produced collagen (in green), illustrating that the 3D cell culture system supports the bone-forming process.

If you want to learn more about the P3D Scaffolds, please visit our Resources page or book a free research consultation with our Scientific Team:​​

Upregulated expression of the alkaline phosphatase gene

April 28, 2022 | News from the Lab​

Alkaline phosphatase plays a vital role in osteogenesis and bone formation and is one of three identified osteogenic marker genes. At Ossiform, we are happy to show new preliminary data which indicates that osteoblasts cultured on the P3D Scaffolds have an upregulated expression of the alkaline phosphatase gene when compared to traditional cell culturing.

These data suggests that the P3D Scaffolds are beneficial for the osteogenic program in vitro on a transcriptional level, thereby supporting their natural genetic fate.

Want to discuss how you can use the 3D cell culture systems in your study? Book an online research consultation with our Scientific Team to learn more and request your sample. 

New scientific paper on Ossiform's P3D Bone​

March 14​, 2022 | News from the Lab

In this newly published paper, Ossiform has compared its 3D printed P3D Bone implant with an off-the-shelf b-TCP implant. The implants were inserted in the mandible ramus of pigs, and after six months, resorption and remodeling were evaluated using CT-scans and histological images. 

After six months, the P3D Bone implants were almost completely resorbed and replaced by vascularized compact bone, allowing osteointegration to occur.​ The histological image in the upper right corner shows the partially resorbed P3D Bone implant only three months after implantation. 

The full results supported by histology and CT data are published in Bone, Volume 159, June 2022. 

Fresh from the Scanning Electron Microscope

​March 3, 2022 | News from the Lab

​Earlier this week, our in-house scientist, Nanna, used SEM imaging to evaluate if osteoblasts cultured on the P3D Scaffolds are producing collagen. This led to several intriguing images that show a large amount of collagen produced. 

The picture shown in this weeks "News from the Lab" illustrates how the P3D Scaffolds allow osteoblasts to produce an extra cellular matrix that spans throughout the scaffold in an in vivo like manner.

If you want to learn more about culturing of cells on our P3D scaffolds, please visit our resources page.

Our mission is your benefits

Our mission is to provide 3D printed natural bone implants to reduce complications, improve functional & aesthetic outcomes, and obtain faster recovery.

Natural bone porosity, optimized for bone regeneration 

The unique structure of the P3D Bone is designed to facilitate the natural forming of new bone.

Remodels into real living bone

The natural material and structure ensure effective remodeling of the implant into new vascularized bone.

Patient specific - designed with the patient's uniqueness in mind

The P3D Bone is 3D printed to enable a full restoration of the functionality and appearance of bones.

Resorbable material with structural support

P3D Bone eliminates the need to harvest bone as well as the need for permanent and ill-fitting implants.

P3D Bone Void Filler is expected to launch in 2023

Our first 3D printed, resorbable P3D Bone with modifiable dimensions and a lifelike bone architecture

P3D Bone Patient Specific Implant is expected to launch in 2024

Our patient specific and resorbable P3D Bone based on the patient’s own CT/MRI scan data

We Print Bone​™

Contact us here

Contact us for questions, general inquiries, or to request a quote.
We strive to provide you with highest quality service and expertise in medical 3D printing.

 
 
 
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Give us a call or write to us by email: info@ossiform.com

We will get back to you as soon as possible.​

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Ossiform ApS - We Print Bone™

​Oslogade 1, 5000 Odense C​, Denmark

CVR. 38838512

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