Patient-Matched and Resorbable

Patient-Matched and Resorbable Bone Graft Substitutes

Ossiform is developing P3D Bone PMI, a new generation of fully resorbable patient-matched bone implants. The P3D Bone is polymer free and printed with a unique bone-like porosity that allows for an effective remodeling into native bone. The result is a more natural implant in terms of both material, shape, and structure.

P3D Bone demonstrates osteoconduction with a rapid formation of new vascularized bone, osseointegration with native bone, and a simultaneous and balanced bioresorption.

The P3D Bone PMI requires no manual adjustment in the operating room and eliminates the need to harvest bone as well as the need for permanent and ill-fitting implants. With P3D Bone, surgeons will be able to provide an implant that precisely matches patient needs, and thereby improve patient outcomes, increase procedural efficiency, and minimize the risk of complications.​

The P3D Bone illustrations shown on this site are intended to demonstrate potential use cases. Products have not cleared by the regulatory authorities and are therefore not approved for sale.

Tricalcium Phosphate: The Optimal Synthetic Choice

Over the past 40 years, bioceramic materials have proven very attractive bone graft substitutes, with beta-tricalcium phosphate (β-TCP) and hydroxyapatite (HA) being some of the most frequently used due to their osteoconductive and osteoinductive properties. 

While the two are sometimes mistaken for one another due to their chemical similarities, β-TCP has been proven to have superior properties compared to HA in terms of cell-mediated resorption and osteoconductivity several times. As a result of these desirable features, β-TCP has been widely used for filling and reconstructing bony defects in orthopedic surgery and dentistry.

Furthermore, the resorption rate and mechanical properties of the β-TCP bone graft substitute can be controlled via its 3D printed design to ensure structural stability throughout the healing process. 

Intended Use Case of P3D Bone PSI

Step 1​


The hospital or clinic performs a CT or MRI scan of the patient which is sent to Ossiform.

Step 2

3D Modeling

Based on the scan, Ossiform 3D models the patient-matched implant using a software tool.

Step 3

Implant Design

The surgeon accepts an implant design, and this is sent to a conveniently located production hub.

Step 4

Ossiform Production Hub

The Ossiform production hub prints, sterilizes and freights the implant to the hospital or clinic.

Step 5


The hospital or clinic receives the implant from the nearby production hub and performs the surgery.

Effective Bone Reconstruction and 3D osteotransduction

P3D Bone is 3D printed with large interconnected and multidirectional macropores and canals to enhance cell attachment, growth, and migration and enable vascularization throughout the entire implant. This mimics the cancellous structure observed in human bones and induces the osteotransduction process.

The porous structure, containing physiologically relevant micro- and macropores, enables a strong ingrowth of new native bone. Meanwhile, the implant’s bone-like chemical composition and structure provides ideal conditions for a simultaneous and stabile resorption. This process ensures an effective remodeling of the implant into new vascularized bone.

Thygesen, T., et al. Comparison of off-the-shelf β-tricalcium phosphate implants with novel resorbable 3D printed implants in mandible ramus of pigs. Bone (2022): 116370.

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Jensen MB, et al. Treating mouse skull defects with 3D printed fatty acid and tricalcium phosphate implants. Journal of Tissue Engineering and Regenerative Medicine. (2020): 1-11

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Jensen MB, et al. Composites of fatty acids and ceramic powders are versatile biomaterials for personalized implants and controlled release of pharmaceuticals. Bioprinting 10 (2018): e00027

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Slots C, et al. Simple additive manufacturing of an osteoconductive ceramic using suspension melt extrusion. Dental Materials 33.2 (2017): 198-208.

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That's why, We Print Bone

Our mission is to provide 3D printed natural bone implants to reduce complications, improve functional outcomes, and obtain faster recovery

Tailored mix of cortical and cancellous components, optimized for bone regeneration and indication-specific biomechanics

Fully remodels into new vascularized bone, leaving nothing but natural bone

Patient matched designed with the patient's uniqueness and biomechanical factors in mind

Resorbable material with structural support, tuned to offer balanced rates of resorption and new bone ingrowth 

P3D Bone Extremities Wedge – approval process ongoing

Our first 3D printed, resorbable P3D Bone with modifiable dimensions and a bone-like morphology

P3D Bone - further products under development

The next generation of resorbable and structural bone implants

We Print Bone​™

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We strive to provide you with highest quality service and expertise in medical 3D printing.

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Ossiform ApS - We Print Bone™

​Oslogade 1, 5000 Odense C​, Denmark

CVR. 38838512

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