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P3D Bone - Patient Specific and Resorbable

Patient Specific and Resorbable Bone Graft Substitutes

Ossiform is developing P3D Bone PSI, a new generation of fully resorbable patient specific bone implants. The P3D Bone is polymer free and printed with a unique bone-like porosity that allows for an effective remodeling into native bone. The result is a more natural implant in terms of both material, shape, and structure.

P3D Bone demonstrates osteoconduction with a rapid formation of new vascularized bone, osseointegration with native bone, and a simultaneous and balanced bioresorption.

The P3D Bone PSI requires no manual adjustment in the operating room and eliminates the need to harvest bone as well as the need for permanent and ill-fitting implants. With P3D Bone, surgeons will be able to provide an implant that precisely matches patient needs, and thereby improve patient outcomes, increase procedural efficiency, and minimize the risk of complications.​

The P3D Bone illustrations shown on this site are intended to demonstrate potential use cases. Products have not cleared by the regulatory authorities and are therefore not approved for sale.

Tricalcium Phosphate: The Optimal Synthetic Choice

Over the past 40 years, bioceramic materials have proven very attractive bone graft substitutes, with beta-tricalcium phosphate (β-TCP) and hydroxyapatite (HA) being some of the most frequently used due to their osteoconductive and osteoinductive properties. 

While the two are sometimes mistaken for one another due to their chemical similarities, β-TCP has been proven to have superior properties compared to HA in terms of cell-mediated resorption and osteoconductivity several times. As a result of these desirable features, β-TCP has been widely used for filling and reconstructing bony defects in orthopedic surgery and dentistry.

Furthermore, the resorption rate and mechanical properties of the β-TCP bone graft substitute can be controlled via its 3D printed design to ensure structural stability throughout the healing process. 

Intended Use Case of P3D Bone PSI

Step 1​


The hospital or clinic performs a CT or MRI scan of the patient which is sent to Ossiform.

Step 2

3D Modeling

Based on the scan, Ossiform 3D models the patient specific implant using a software tool.

Step 3

Implant Design

The surgeon accepts an implant design, and this is sent to a conveniently located production hub.

Step 4

Ossiform Production Hub

The Ossiform production hub prints, sterilizes and freights the implant to the hospital or clinic.

Step 5


The hospital or clinic receives the implant from the nearby production hub and performs the surgery.

Effective Bone Reconstruction and 3D Bone Regeneration

P3D Bone is 3D printed with large interconnected and multidirectional macropores and canals to enhance cell attachment, growth, and migration and enable vascularization throughout the entire implant. This mimics the cancellous structure observed in human bones and induces the bone regeneration process.

The porous structure, containing physiologically relevant micro- and macropores, enables a strong ingrowth of new native bone. Meanwhile, the implant’s bone-like chemical composition and structure provides ideal conditions for a simultaneous and stabile resorption. This process ensures an effective remodeling of the implant into new vascularized bone.

Jensen, M. B., Slots, C., Ditzel, N., Albrektsen, O., Borg, S., Thygesen, T., … & Andersen, M. Ø. (2018). Composites of fatty acids and ceramic powders are versatile biomaterials for personalized implants and controlled release of pharmaceuticals. Bioprinting, 10, e00027.

Fernandez de Grado G, Keller L, Idoux-Gillet Y, Wagner Q, Musset AM, Benkirane-Jessel N, et al. Bone substitutes: a review of their characteristics, clinical use, and perspectives for large bone defects management. J Tissue Eng. 2018;9:2041731418776819.​

Shekhawat D, Singh A, Banerjee MK, Singh T, Patnaik A. Bioceramic composites for orthopaedic applications: A comprehensive review of mechanical, biological, and microstructural properties. Ceram Int. 2021;47(3):3013-3030. doi:10.1016/J.CERAMINT.2020.09.214

​Thygesen, T., et al. Comparison of off-the-shelf β-tricalcium phosphate implants with novel resorbable 3D printed implants in mandible ramus of pigs. Bone (2022): 116370.

Onodera J, Kondo E, Omizu N, Ueda D, Yagi T, Yasuda K. Beta-tricalcium phosphate shows superior absorption rate and osteoconductivity compared to hydroxyapatite in open-wedge high tibial osteotomy. Knee Surg Sports Traumatol Arthrosc. 2014;22(11):2763-2770. 

Oh KJ, Ko YB, Jaiswal S, Whang IC. Comparison of osteoconductivity and absorbability of beta-tricalcium phosphate and hydroxyapatite in clinical scenario of opening wedge high tibial osteotomy. J Mater Sci Mater Med. 2016;27(12). 

Ogose A, Hotta T, Kawashima H, et al. Comparison of hydroxyapatite and beta tricalcium phosphate as bone substitutes after excision of bone tumors. J Biomed Mater Res B Appl Biomater. 2005;72B(1):94-101. 

Rojbani H, Nyan M, Ohya K, Kasugai S. Evaluation of the osteoconductivity of α-tricalcium phosphate, β-tricalcium phosphate, and hydroxyapatite combined with or without simvastatin in rat calvarial defect. J Biomed Mater Res A. 2011;98(4):488-498. 

That's why, We Print Bone

Our mission is to provide 3D printed natural bone implants to reduce complications, improve functional & aesthetics outcomes, and obtain faster recovery

Natural bone porosity, optimized for bone regeneration

The unique structure of the P3D Bone is designed to facilitate the natural forming of new bone.

Remodels into real living bone

The natural material and structure ensure effective remodeling of the implant into new vascularized bone.

Patient specific - designed with the patient's uniqueness in mind

The P3D Bone is 3D printed to enable a full restoration of the functionality and appearance of bones. ​

Resorbable material with structural support

P3D Bone eliminates the need to harvest bone as well as the need for permanent and ill-fitting implants.

P3D Bone Void Filler is expected to launch in 2023

Our first 3D printed, resorbable P3D Bone with modifiable dimensions and a lifelike bone architecture.

P3D Bone Patient Specific Implant is expected to launch in 2024

Our patient specific and resorbable P3D Bone based on the patient's own CT/MRI scan data. ​

We Print Bone​™

Contact us here

Contact us for questions, general inquiries, or to request a quote.
We strive to provide you with highest quality service and expertise in medical 3D printing.

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Do you have questions?

Give us a call or send us an email: info@ossiform.com

We will get back to you as soon as possible.​

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Ossiform ApS - We Print Bone™

​Oslogade 1, 5000 Odense C​, Denmark

CVR. 38838512

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