The Bone Printing Solution

Ossiform is founded on a worldwide IP protected technology invented while investigating the possibility of 3D printing bone implants for human use.

Our solution is a bio-ink composed of powder particles suspended in a solid but meltable fatty acid matrix. The bio-ink enables a new 3D additive manufacturing process where objects are constructed directly from a computer-aided design (CAD) file.

The bio-ink is loaded into a syringe, heated to its melting point and extruded as a thin line onto a cooler stage on which it re-solidifies. The fatty acid is then removed through burning and the powders are sintered together.

The technology is patented worldwide, and can be used with many materials and in many industries beyond the medical field.

Good Preclinical Proof

Good preclinical proof demonstrates that the P3D Bone implants perform as well as predicted.

The implants are mechanically strong and free from contaminants,
support the rapid formation of new vascularized bone,
integrate with neighboring bone in vivo, and
show clear signs of implant resorption and no signs of infection.

These results have been published in well-recognized scientific papers (See Publications section below).

Ossiform’s bone printing technology will allow surgeons to reconstruct bone with the patient’s uniqueness and biomechanical factors in mind

The internal bone-like porosity, obtained through 3D printing, allows for a strong and rapid ingrowth of bone tissue and low risk of complications, as the immune system is allowed access to the entirety of the implant.

We work in close collaboration with surgeons to provide natural implants that are printed for each individual patient, based on CT or MRI scan data, to provide exact anatomic repair. This improves patient outcomes ― both functional and aesthetic ― and reduces operating time as the surgeon does not need to manually adjust the implant during surgery.

Drug releasing bone implants

Ossiform’s laboratory tests have also shown that P3D Bone implants can be designed to deliver additives such as growth factors, antibiotics, and chemotherapy with wide ranging benefits for patients.

Tests have shown that the resorption speed and release rate of the pharmaceutical can be controlled by varying the fatty acid tail length. This will allow for a local long-term controlled drug release and thereby a more effective way of dosing medication which reduces the amount of the drug needed. This helps contain costs, reduces the development of resistant bacteria and benefits patients, as lower doses are less harmful to the liver and kidneys that metabolize the drug.

Please contact us for more information about this current area of R&D activity.

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Publications

Thygesen, T., et al. Comparison of off-the-shelf β-tricalcium phosphate implants with novel resorbable 3D printed implants in mandible ramus of pigs. Bone (2022): 116370.

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Jensen MB, et al. Treating mouse skull defects with 3D printed fatty acid and tricalcium phosphate implants. Journal of Tissue Engineering and Regenerative Medicine. (2020): 1-11

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Jensen MB, et al. Composites of fatty acids and ceramic powders are versatile biomaterials for personalized implants and controlled release of pharmaceuticals. Bioprinting 10 (2018): e00027

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Slots C, et al. Simple additive manufacturing of an osteoconductive ceramic using suspension melt extrusion. Dental Materials 33.2 (2017): 198-208.

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Jensen MB et al. The performance of a new generation of 3D printed and drug and stem cell loaded implants in vitro and in vivo. DASCS2017 Stem Cell Conference. 2017.

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That's why, We Print Bone™

Our mission is to provide 3D printed natural bone implants to reduce complications, improve functional outcomes, and obtain faster recovery

Tailored mix of cortical and cancellous components, optimized for bone regeneration and indication-specific biomechanics

Fully remodels into new vascularized bone, leaving nothing but natural bone

Patient matched – designed with the patient's uniqueness and biomechanical factors in mind

Resorbable material with structural support, tuned to offer balanced rates of resorption and new bone ingrowth

P3D Bone Extremities Wedge – approval process ongoing

Our first 3D printed, resorbable P3D Bone with modifiable dimensions and a bone-like morphology

P3D Bone - further products under development

The next generation of resorbable and structural bone implants

We Print Bone™

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Contact us for questions, general inquiries, or to request a quote.
We strive to provide you with highest quality service and expertise in medical 3D printing.

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