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3D printing ceramic structures​

Ossiform is founded on a widely applicable and worldwide IP protected technology invented while investigating the possibility of 3D printing bone implants for human use.

Our solution is a bio-ink composed of powder particles suspended in a solid but meltable fatty acid matrix. The bio-ink enables a new 3D additive manufacturing process where objects are constructed directly from a computer-aided design (CAD) file. 

The bio-ink is loaded into a syringe, heated to its melting point and extruded as a thin line onto a cooler stage on which it re-solidifies. The fatty acid is then removed through burning and the powders are sintered together.

The invention can be used with many materials and in many industries beyond the medical field.

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Good Preclinical Proof

Good preclinical proof demonstrates that the P3D Bone implants perform as well as predicted.

  • The implants are mechanically strong and free from contaminants,
  • support the rapid formation of new vascularized bone,
  • integrate with neighboring bone in vivo, and
  • show clear signs of implant resorption and no signs of infection.

These results have been published in well-recognized scientific papers (See Publications section below).

3D printing natural biomaterials

Ossiform’s novel technology will allow surgeons to reconstruct bone with the patient’s uniqueness in mind.

The internal bone-like porosity, obtained through 3D printing, allows for a strong and rapid ingrowth of bone tissue and low risk of complications, as the immune system is allowed access to the entirety of the implant.

We work in close collaboration with surgeons to provide natural implants that are printed for each individual patient, based on CT or MRI scan data, to provide exact anatomic repair. This improves patient outcomes ― both functional and aesthetic ― and reduces operating time as the surgeon does not need to manually adjust the implant during surgery.​

Drug releasing bone implants

Ossiform’s laboratory tests have also shown that P3D Bone implants can be designed to deliver additives such as growth factors, antibiotics, and chemotherapy with wide ranging benefits for patients.

Tests have shown that the resorption speed and release rate of the pharmaceutical can be controlled by varying the fatty acid tail length. This will allow for a local long-term controlled drug release and thereby a more effective way of dosing medication which reduces the amount of the drug needed. This helps contain costs, reduces the development of resistant bacteria and benefits patients, as lower doses are less harmful to the liver and kidneys that metabolize the drug.

Please contact us for more information about this current area of R&D activity. 

​Publications

Thygesen, T., et al. Comparison of off-the-shelf β-tricalcium phosphate implants with novel resorbable 3D printed implants in mandible ramus of pigs. Bone (2022): 116370.

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Jensen MB, et al. Treating mouse skull defects with 3D printed fatty acid and tricalcium phosphate implants. Journal of Tissue Engineering and Regenerative Medicine. (2020): 1-11

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Jensen MB, et al. Composites of fatty acids and ceramic powders are versatile biomaterials for personalized implants and controlled release of pharmaceuticals. Bioprinting 10 (2018): e00027

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Slots C, et al. Simple additive manufacturing of an osteoconductive ceramic using suspension melt extrusion. Dental Materials 33.2 (2017): 198-208. 

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Jensen MB et al. The performance of a new generation of 3D printed and drug and stem cell loaded implants in vitro and in vivo. DASCS2017 Stem Cell Conference. 2017.

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Our mission is your benefits

Our mission is to provide 3D printed natural bone implants to reduce complications, improve functional & aesthetic outcomes, and obtain faster recovery.

Natural bone porosity, optimized for bone regeneration 

The unique structure of the P3D Bone is designed to facilitate the natural forming of new bone.

Remodels into real living bone

The natural material and structure ensure effective remodeling of the implant into new vascularized bone.

Patient specific - designed with the patient's uniqueness in mind

The P3D Bone is 3D printed to enable a full restoration of the functionality and appearance of bones.

Resorbable material with structural support

P3D Bone eliminates the need to harvest bone as well as the need for permanent and ill-fitting implants.

P3D Bone Void Filler is expected to launch in 2023

Our first 3D printed, resorbable P3D Bone with modifiable dimensions and a lifelike bone architecture

P3D Bone Patient Specific Implant is expected to launch in 2024

Our patient specific and resorbable P3D Bone based on the patient’s own CT/MRI scan data

We Print Bone​™

Contact us here

Contact us for questions, general inquiries, or to request a quote.
We strive to provide you with highest quality service and expertise in medical 3D printing.

 
 
 
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Do you have questions?

Give us a call or write to us by email: info@ossiform.com

We will get back to you as soon as possible.​

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Ossiform ApS - We Print Bone™

​Oslogade 1, 5000 Odense C​, Denmark

CVR. 38838512

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