Ossiform Research Line
What are the P3D Scaffolds?
Bioceramic bone-mimicking scaffolds, a clinically relevant and animal-free alternative, for your cell- and bacteria studies, tissue engineering, disease modeling, and drug screening.
The 3D printed structures mimic the physical properties of calcified bone tissue to let you create more relevant and predictable models of human physiology and pathology that capture the complex interplay between various cells.
Not certified for clinical or diagnostic purposes.
Benefits
- No batch to batch variance
- Enable co-culturing and cell seeding at different time points
- Maintain relevant cell signaling
- Support the natural self-organization of cells
- Easily apply 2D analysis methods
- Biocompatible, for in vitro and in vivo research
- Delivered sterile and ready to use
- Animal-free alternative
- Stable structures: easy management
Mimic hard tissue in vitro with 100% polymer-free bioceramic scaffolds
The idea behind P3D Scaffolds is to give researchers the opportunity to perform their in vitro experiments in a clinically relevant context.
The porous 3D structure supports the natural self-organization of cells and maintains relevant cell signaling. It can also be used to test new therapies in lifelike structures wherein drug perfusion is uneven and where bacteria and cancer cells may hide in pores. This allows for a more realistic testing that is more likely to yield reliable results when subsequently translated.
Easy-to-use and compatible with common in vitro techniques
The P3D Scaffolds are compatible with most laboratory techniques with little to no alterations to the existing protocol.
By enabling the creation of more relevant cell culture models, we aim to help researchers enhance in vitro research and accelerate the development of new human therapies while reducing the need for animal testing.
Why 3D Printed Scaffolds?
The porosities maximize the surface area onto which cells can attach. Researchers can add different cells and pharmaceuticals to study how they interact with each other and the structure within its pores. For example:
- Mesenchymal stem cells or osteoblasts can be added onto the P3D Scaffold to study how new bone develops in bone grafts.
- Bone destruction in osteoporosis/arthritis can be imitated by seeding osteoclasts and macrophages onto the scaffolds.
- The development of bone tumors and spreading of cancerous cells through the outer calcified bone matrix can be studied by seeding cancerous cells onto the P3D Scaffolds.
- Osteomyelitis and the subsequent destruction of bone can be mimicked by adding bacteria and immune cells. This enables you to study the mechanisms behind the bacteria’s destruction of the hardened calcified bone as well as how bacteria are able to evade the immune system and antimicrobial pharmaceuticals.
Why Tricalcium Phosphate?
The P3D Scaffolds are made from a nonpolymeric bioink consisting of β-TCP which facilitates a realistic cell differentiation and proliferation.
As the scaffolds are made of β-TCP instead of HA, you can easily distinguish between mineral from the scaffold and mineral deposited by osteoblasts. While β -TCP is not the exact mineral that our bones are composed of, the bone-interacting cells perceives it as such.
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Patent status: The product is protected by one or more US, European, and/or foreign patents.
Disclaimer: The products are “For Research Use Only (RUO)” and should not be used for clinical purposes. Ossiform® makes no other warranties, expressed or implied, including the implied warranty of merchantability and the implied warranty of fitness for particular purpose.