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Ossiform Research Line
P3D Scaffolds and customized bone models
What are the P3D Scaffolds?
Bioceramic bone-mimicking scaffolds, a clinically relevant and animal-free alternative, for your cell- and bacteria studies, tissue engineering, disease modeling, and drug screening.
The 3D printed structures mimic the physical properties of calcified bone tissue to let you create more relevant and predictable models of human physiology and pathology that capture the complex interplay between various cells.
Not certified for clinical or diagnostic purposes.
Benefits
- No batch to batch variance
- Enable co-culturing and cell seeding at different time points
- Maintain relevant cell signaling
- Support the natural self-organization of cells
- Easily apply 2D analysis methods
- Biocompatible, for in vitro and in vivo research
- Delivered sterile and ready to use
- Animal-free alternative
- Stable structures: easy management
Mimic hard tissue in vitro with 100% polymer-free bioceramic scaffolds
The idea behind P3D Scaffolds is to give researchers the opportunity to perform their in vitro experiments in a clinically relevant context.
The porous 3D structure supports the natural self-organization of cells and maintains relevant cell signaling. It can also be used to test new therapies in lifelike structures wherein drug perfusion is uneven and where bacteria and cancer cells may hide in pores. This allows for a more realistic testing that is more likely to yield reliable results when subsequently translated.
Easy-to-use and compatible with common in vitro techniques
The P3D Scaffolds are compatible with most laboratory techniques with little to no alterations to the existing protocol.
By enabling the creation of more relevant cell culture models, we aim to help researchers enhance in vitro research and accelerate the development of new human therapies while reducing the need for animal testing.
Testimonials
David Steele, Managing Director, Biocolor Ltd.
At Biocolor we produce tools to enable user-friendly scientific measurement of ECM biomolecules. We were introduced to Ossiform through a mutual supplier and have collaborated with them for the last couple of years to adapt our collagen measurement kits to their range of ‘P3D’, bone-mimicking scaffolds.
We have found their P3D scaffold systems to be of consistently high quality, having tested several variants across the range. In addition, we have found the Ossiform team to be forward-looking, friendly and engaging to work with. We would recommend their product and the team to anyone.
Madison Skye Chacon, Bioenergetics, Glucocorticoids & 3R-Research, Charité - University of Medicine, Berlin
We have been using the Ossiform grid 5 mm diameter scaffolds in our 3D bone models for the past six months and have been very satisfied with both the products and the customer support we have received. The uniformity of the scaffolds has added a level of standardization to our model that was not possible with our previous scaffolds. For example, the Ossiform scaffolds have allowed us to optimize our cell seeding density with much greater precision. The uniformity of the scaffolds has also been beneficial for longitudinal uCT imaging, allowing us to track changes in our model over time.
In addition, the customer support from Ossiform has been outstanding. Our representative took the time to meet with our team to discuss the needs of our project and recommend the most suitable product. We were provided with trial scaffolds for evaluation, and Ossiform remained responsive throughout the selection, ordering, and implementation process. They have continued to follow up to ensure that we are satisfied with the products and to answer any questions that arise. We would highly recommend Ossiform to researchers looking for high-quality, standardized scaffolds and excellent customer support.
Luis Eduardo Carneiro-Campos, Associate Professor, Fluminense Federal University (UFF), Brazil
In August 2020, in the midst of the pandemic, I was sharing ideas and research interests around biofabrication when Ossiform became one of the companies following my work. Through Monica Wellejus, that first connection quickly became a scientific dialogue. Just a few days later, the first biofabricated β-TCP scaffolds arrived at Fluminense Federal University (UFF), Brazil, for investigation.
At that time, the company was still a young startup from the University of Southern Denmark. Six years later, I have had the privilege of watching that early idea grow into Ossiform, a company reaching markets worldwide while continuing to push the boundaries of 3D-printed solutions for bone regeneration.
For me, the most valuable outcome of this collaboration has never been simply the scaffold. It has been the knowledge we have built together — through research, challenges, publications, and the continuous exchange between science and technology.
Why 3D Printed Scaffolds?
The porosities maximize the surface area onto which cells can attach. Researchers can add different cells and pharmaceuticals to study how they interact with each other and the structure within its pores. For example:
- Mesenchymal stem cells or osteoblasts can be added onto the P3D Scaffold to study how new bone develops in bone grafts.
- Bone destruction in osteoporosis/arthritis can be imitated by seeding osteoclasts and macrophages onto the scaffolds.
- The development of bone tumors and spreading of cancerous cells through the outer calcified bone matrix can be studied by seeding cancerous cells onto the P3D Scaffolds.
- Osteomyelitis and the subsequent destruction of bone can be mimicked by adding bacteria and immune cells. This enables you to study the mechanisms behind the bacteria’s destruction of the hardened calcified bone as well as how bacteria are able to evade the immune system and antimicrobial pharmaceuticals.
Why Tricalcium Phosphate?
The P3D Scaffolds are made from a nonpolymeric bioink consisting of β-TCP which facilitates a realistic cell differentiation and proliferation.
As the scaffolds are made of β-TCP instead of HA, you can easily distinguish between mineral from the scaffold and mineral deposited by osteoblasts. While β -TCP is not the exact mineral that our bones are composed of, the bone-interacting cells perceives it as such.
Want assistance with your next
research project?
We are committed to using our expertise in medical 3D printing to help meet your specific research needs.
Patent status: The product is protected by one or more US, European, and/or foreign patents.
Disclaimer: The products are “For Research Use Only (RUO)” and should not be used for clinical purposes. Ossiform® makes no other warranties, expressed or implied, including the implied warranty of merchantability and the implied warranty of fitness for particular purpose.