Technology
The Bone Printing Solution
Ossiform® is founded on a worldwide IP protected technology invented while investigating the possibility of 3D printing bone implants for human use.
Our solution is a bio-ink composed of powder particles suspended in a solid but meltable fatty acid matrix. The bio-ink enables a new 3D additive manufacturing process where objects are constructed directly from a computer-aided design (CAD) file.
The bio-ink is loaded into a syringe, heated to its melting point and extruded as a thin line onto a cooler stage on which it re-solidifies. The fatty acid is then removed through burning and the powders are sintered together.
The technology is patented worldwide, and can be used with many materials and in many industries beyond the medical field.
Good Preclinical Proof
Good preclinical proof demonstrates that the P3D Bone implants perform as well as predicted.
- The implants are mechanically strong and free from contaminants,
- support the rapid formation of new vascularized bone,
- integrate with neighboring bone in vivo, and
- show clear signs of implant resorption and no signs of infection.
These results have been published in well-recognized scientific papers (See Publications section below).
Ossiform®’s bone printing technology will allow surgeons to reconstruct bone with the patient’s uniqueness and biomechanical factors in mind
We work in close collaboration with surgeons to provide natural implants that are optimized for the specific demands of diversified clinical applications with an aim to improve bone healing outcomes and minimize revision surgeries within orthopedic surgery and spine fusion.
The internal bone-like porosity, obtained through 3D printing, allows for a strong and rapid ingrowth of bone tissue and low risk of complications, as the immune system is allowed access to the entirety of the implant.
Publications
Thygesen, T., et al. Comparison of off-the-shelf β-tricalcium phosphate implants with novel resorbable 3D printed implants in mandible ramus of pigs. Bone (2022): 116370.
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Jensen MB, et al. Treating mouse skull defects with 3D printed fatty acid and tricalcium phosphate implants. Journal of Tissue Engineering and Regenerative Medicine. (2020): 1-11
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Jensen MB, et al. Composites of fatty acids and ceramic powders are versatile biomaterials for personalized implants and controlled release of pharmaceuticals. Bioprinting 10 (2018): e00027
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Slots C, et al. Simple additive manufacturing of an osteoconductive ceramic using suspension melt extrusion. Dental Materials 33.2 (2017): 198-208.
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Jensen MB et al. The performance of a new generation of 3D printed and drug and stem cell loaded implants in vitro and in vivo. DASCS2017 Stem Cell Conference. 2017.
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