​News from the Lab

P3D Scaffolds support normal morphology of osteoblasts

P3D Scaffolds support normal morphology of osteoblasts

Our latest studies have shown that the P3D Scaffolds have great osteogenic properties and that osteoblasts maintain their genotype and morphological phenotype. We have had the osteoblasts cultured for 2-5 weeks and the results are clear.

Osteoblastic marker genes are upregulated in response to traditional cell culturing. Confocal imaging shows how the P3D scaffolds allow the osteoblasts to organize in a 3D oriented manner, surrounded by their collagen-rich extracellular matrix.

Studying the osteoblasts and their extracellular matrix closer using scanning electron microscopy, you can really appreciate how the osteoblasts are retaining their round morphology, and how the extracellular matrix is spanning widely across the scaffold clearly indicative of the first steps in bone formation.