Since launching the Grant Campaign in May 2023, Ossiform® has successfully provided researchers at the University of Oxford and the University of Southern Denmark with P3D Scaffolds, to help simulate an in vivo environment.

About the research team from the University of Oxford

​Currently, the prevention of prostate cancer bone metastasis is halted by palliative treatments, limited preclinical secondary bone cancer models, and low take rates when using animal models. Consequently, no curative treatment exists for this cancer stage. However, researchers at the University of Oxford, led by Jia-Ling Ruan, aspire to advance appropriate therapies by integrating Ossiform’s P3D Scaffolds in their 3D tumor/organoid cultures, to develop an effective in vitro bone metastasis model. Utilizing FLASH radiotherapy, the researchers can buoyantly study the effects of radiation responses of normal bone tissue/tumor and the abscopal effects of secondary bone metastasis, respectively.

About the research team from the University of Southern Denmark

A plethora of publications have elucidated detailed molecular- and biophysical mechanisms of membrane transporters and their substrates using static 2D cultures. However, much less has been published about how cells effectively maneuver the complex 3D environments of living tissues. A research team from the University of Southern Denmark, led by Professor Carsten Uhd Nielsen, aims to study the function of membrane transporters using Ossiform®’s P3D Scaffolds as an appropriate platform. With this technology, the group aspires to simulate a dynamic in vivo like environment to facilitate pharmaceutical applications of membrane transporter.